JCPM2022.07.26. Central Effect of BOTOX. Botox for ED & Bruxism

Topics Discussed Include the Following…

*Botox for bruxism-the central effect
*PRP for peptic ulcer disease
*Botox for erectile dysfunction

Video/Recording of CMA Journal Club, Pearl Exchange, & Marketing Tips

Relevant Research, Relevant Links (includes how to inject the penis with Botox)<–

Research Review

The central nervous system effects of Botox and how those effects may benefit in the treatments of Bruxism and erectile dysfunction with Botox

  1. Mazzocchio R, Caleo M. More than at the Neuromuscular Synapse: Actions of Botulinum Neurotoxin A in the Central Nervous System. Neuroscientist. 2015;21(1):44-61. doi:10.1177/1073858414524633
  2. Caleo M, Restani L. Direct central nervous system effects of botulinum neurotoxin. Toxicon. 2018;147:68-72. doi:10.1016/j.toxicon.2017.10.027


1.Abdelrahman IFS, Raheem AA, Elkhiat Y, Aburahma AA, Abdel-Raheem T, Ghanem H. Safety and efficacy of botulinum neurotoxin in the treatment of erectile dysfunction refractory to phosphodiesterase inhibitors: Results of a randomized controlled trial. Andrology. 2022;10(2):254-261. doi:10.1111/andr.13104
2. El-Shaer W, Ghanem H, Diab T, Abo-Taleb A, Kandeel W. Intra-cavernous injection of BOTOX® (50 and 100 Units) for treatment of vasculogenic erectile dysfunction: Randomized controlled trial. Andrology. 2021;9(4):1166-1175. doi:10.1111/andr.13010


Ågren M, Sahin C, Pettersson M. The effect of botulinum toxin injections on bruxism: A systematic review. Journal of Oral Rehabilitation. 2020;47(3):395-402. doi:10.1111/joor.12914

Fernández-Núñez T, Amghar-Maach S, Gay-Escoda C. Efficacy of botulinum toxin in the treatment of bruxism: Systematic review. Med Oral Patol Oral Cir Bucal. 2019;24(4):e416-e424. doi:10.4317/medoral.22923

Caleo M, Restani L. Direct central nervous system effects of botulinum neurotoxin. Toxicon. 2018;147:68-72. doi:10.1016/j.toxicon.2017.10.027

Renshaw cells (affected by BOTOX)<–

Research regarding the P-Shot® for ED<==

Treating peptic ulcer disease with PRP

  1. Xu T, Tian Y, Wang Y, et al. Effects of Autologous Platelet-Rich Plasma on Healing of Peptic Ulcers: A Randomized Controlled Trial. M’Koma A, ed. Gastroenterology Research and Practice. 2022;2022:1-9. doi:10.1155/2022/7944849
Next Hands-On Workshops with Live Models<---

Question from Members

The current question I have is concerning a P-Shot, I administered on an 80 yr old male. He wanted to try it not necessarily for ED. But more for relief of urinary frequency. He has no history Of Prostate Cancer, his PSA levels are low, and < a week after the P-Shot®, he reported improvement in his frequency symptoms (2-3hrs versus q15 minutes). However, he now states his frequency has worsened (q30 minutes).

It has been 3 weeks since the procedure, and I told him we would continue to monitor.

Have you ever seen the P-Shot® relieve urinary frequency in men?

Relevant Links

–>Next class to learn to inject the major joints (knees, elbows, shoulders, Achilles) with PRP<–
–>Apply for Further Online Training for O-Shot®, P-Shot®, Vampire Facelift®, Vampire Breast Lift®, Vampire Wing Lift®, or Vampire Facial®<–
–>Next Hands-on Workshops with Live Models, worldwide <–

–> IMPORTANT (ONLY) IF YOU ARE NEW TO THE CMA: Please take any relevant online tests so that we can immediately list you (and your clinic) on the directories and start supplying you with other helpful marketing and educational materials. Testing takes an hour at most (including watching the videos. If you want to expedite the testing, you can simply call the CMA headquarters (1-888-920-5311 9-5 New York time Mon-Thur; 9-12 Fri) and one of our business consultants will log you in and walk you through where to find the study materials and the tests. If you are already on the directories for the procedure(s) you provide, then you already took the tests or did hand-on training with evaluation by your instructor.

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Charles Runels, MD





Cellular Medicine Association

2 thoughts on “JCPM2022.07.26. Central Effect of BOTOX. Botox for ED & Bruxism”

  1. I’m a urologist who has been doing the P-Shot for about 7 or 8 years. While I have seen the O-shot help many women with urgency and urge incontinence, and hundreds of women helped with stress incontinence, I would not see how a P-shot would help a man with frequency.

    The placement in women may be near enough the detrusor that it helps with urge, and certainly with stress, but penile placement just isn’t in the area that I see that it could help.

    Without more knowledge of the specifics, I’d do the typical DHT blockers and/or something like Flomax.

    1. Thank you very much for letting us know your thoughts. No way I’d disagree with your expertise, nor would I ignore the standard treatments.

      When I get the report from our members about a man’s urinary incontinence being helped by our P-Shot®, I have always said that “I have no idea how it could help other than by the placebo effect.”

      But, your comment made me realize something: all the reports from our members to me, when the P-Shot helps with urinary urgency or incontinence, it’s helping in men who have already had prostate surgery with the mechanical obstruction removed but who still suffer from post-op urgency and/or incontinence; is the P-Shot correcting post-op nerve damage?

      After reading about the central effects of Botox that if there is an effect from our P-Shot® on urinary incontinence in men, I wonder if the mechanism may be similar to the central effect of Botox on the axons and Renshaw cells.

      Put another way: I have not had a report of the P-Shot helping with urgency, frequency, or incontinence except in men post-op from prostate surgery; the mechanical obstruction has been removed, so perhaps the P-Shot® is correcting damage to the nerves of micturition. If that is true, then you (Dr. Ibrahim) would be the best to help us figure out how to make that happen more specifically.

      For erectile dysfunction and today’s JCPM discussion, I am excited about the possibility of combining Botox with our P-Shot® procedure since we now have good studies supporting both PRP and Botox as a treatment for ED.

      Thank you very much for your comment. I’m always eager to hear your take on what we are doing.

      For those new to our group, here’s a sampling of research showing PRP helps with the repair of nerves:

      1. Pandunugrahadi M, Irianto KA, Sindrawati O. The Optimal Timing of Platelet-Rich Plasma (PRP) Injection for Nerve Lesion Recovery: A Preliminary Study. Int J Biomater. 2022;2022:9601547. doi:10.1155/2022/9601547
      2. Chung E. Regenerative technology to restore and preserve erectile function in men following prostate cancer treatment: evidence for penile rehabilitation in the context of prostate cancer survivorship. Therapeutic Advances in Urology. 2021;13:17562872211026420. doi:10.1177/17562872211026421
      3. Sánchez M, Anitua E, Delgado D, et al. Platelet-rich plasma, a source of autologous growth factors and biomimetic scaffold for peripheral nerve regeneration. Expert Opinion on Biological Therapy. 2017;17(2):197-212. doi:10.1080/14712598.2017.1259409
      4. Kuffler DP. Platelet-Rich Plasma and the Elimination of Neuropathic Pain. Mol Neurobiol. 2013;48(2):315-332. doi:10.1007/s12035-013-8494-7
      5. Foy CA, Micheo WF, Kuffler DP. Functional Recovery following Repair of Long Nerve Gaps in Senior Patient 2.6 Years Posttrauma. Plast Reconstr Surg Glob Open. 2021;9(9):e3831. doi:10.1097/GOX.0000000000003831
      6. Yasak T, Özkaya Ö, Ergan Şahin A, Çolak Ö. Electromyographic and Clinical Investigation of the Effect of Platelet-Rich Plasma on Peripheral Nerve Regeneration in Patients with Diabetes after Surgery for Carpal Tunnel Syndrome. Arch Plast Surg. 2022;49(02):200-206. doi:10.1055/s-0042-1744410
      7. Wu YN, Liao CH, Chen KC, Chiang HS. Dual effect of chitosan activated platelet rich plasma (cPRP) improved erectile function after cavernous nerve injury. Journal of the Formosan Medical Association. Published online March 27, 2021. doi:10.1016/j.jfma.2021.01.019

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