JCPM2022.07.26. Central Effect of BOTOX. Botox for ED & Bruxism

Topics Discussed Include the Following…

*Botox for bruxism-the central effect
*PRP for peptic ulcer disease
*Botox for erectile dysfunction

Video/Recording of CMA Journal Club, Pearl Exchange, & Marketing Tips

Relevant Research, Relevant Links

BotoxClass.com (includes how to inject the penis with Botox)<–

Research Review

The central nervous system effects of Botox and how those effects may benefit in the treatments of Bruxism and erectile dysfunction with Botox

  1. Mazzocchio R, Caleo M. More than at the Neuromuscular Synapse: Actions of Botulinum Neurotoxin A in the Central Nervous System. Neuroscientist. 2015;21(1):44-61. doi:10.1177/1073858414524633
  2. Caleo M, Restani L. Direct central nervous system effects of botulinum neurotoxin. Toxicon. 2018;147:68-72. doi:10.1016/j.toxicon.2017.10.027

ED

1.Abdelrahman IFS, Raheem AA, Elkhiat Y, Aburahma AA, Abdel-Raheem T, Ghanem H. Safety and efficacy of botulinum neurotoxin in the treatment of erectile dysfunction refractory to phosphodiesterase inhibitors: Results of a randomized controlled trial. Andrology. 2022;10(2):254-261. doi:10.1111/andr.13104
2. El-Shaer W, Ghanem H, Diab T, Abo-Taleb A, Kandeel W. Intra-cavernous injection of BOTOX® (50 and 100 Units) for treatment of vasculogenic erectile dysfunction: Randomized controlled trial. Andrology. 2021;9(4):1166-1175. doi:10.1111/andr.13010

Bruxism

1.
Ågren M, Sahin C, Pettersson M. The effect of botulinum toxin injections on bruxism: A systematic review. Journal of Oral Rehabilitation. 2020;47(3):395-402. doi:10.1111/joor.12914

2.
Fernández-Núñez T, Amghar-Maach S, Gay-Escoda C. Efficacy of botulinum toxin in the treatment of bruxism: Systematic review. Med Oral Patol Oral Cir Bucal. 2019;24(4):e416-e424. doi:10.4317/medoral.22923

3.
Caleo M, Restani L. Direct central nervous system effects of botulinum neurotoxin. Toxicon. 2018;147:68-72. doi:10.1016/j.toxicon.2017.10.027

Renshaw cells (affected by BOTOX)<–

Research regarding the P-Shot® for ED<==

Treating peptic ulcer disease with PRP

  1. Xu T, Tian Y, Wang Y, et al. Effects of Autologous Platelet-Rich Plasma on Healing of Peptic Ulcers: A Randomized Controlled Trial. M’Koma A, ed. Gastroenterology Research and Practice. 2022;2022:1-9. doi:10.1155/2022/7944849
Next Hands-On Workshops with Live Models<---

Question from Members

The current question I have is concerning a P-Shot, I administered on an 80 yr old male. He wanted to try it not necessarily for ED. But more for relief of urinary frequency. He has no history Of Prostate Cancer, his PSA levels are low, and < a week after the P-Shot®, he reported improvement in his frequency symptoms (2-3hrs versus q15 minutes). However, he now states his frequency has worsened (q30 minutes).

It has been 3 weeks since the procedure, and I told him we would continue to monitor.

Have you ever seen the P-Shot® relieve urinary frequency in men?

Relevant Links

–>Next class to learn to inject the major joints (knees, elbows, shoulders, Achilles) with PRP<–
–>Apply for Further Online Training for O-Shot®, P-Shot®, Vampire Facelift®, Vampire Breast Lift®, Vampire Wing Lift®, or Vampire Facial®<–
–>Next Hands-on Workshops with Live Models, worldwide <–

–> IMPORTANT (ONLY) IF YOU ARE NEW TO THE CMA: Please take any relevant online tests so that we can immediately list you (and your clinic) on the directories and start supplying you with other helpful marketing and educational materials. Testing takes an hour at most (including watching the videos. If you want to expedite the testing, you can simply call the CMA headquarters (1-888-920-5311 9-5 New York time Mon-Thur; 9-12 Fri) and one of our business consultants will log you in and walk you through where to find the study materials and the tests. If you are already on the directories for the procedure(s) you provide, then you already took the tests or did hand-on training with evaluation by your instructor.

O-Shot® CBD Arousal Oil. O-Shot® providers order wholesale by logging into the O-Shot® membership site, or by calling CMA Headquarters.
Altar™–A Vampire Skin Therapy™. All CMA members can order wholesale by logging into the membership sites and going to Dashboard–>Supplies

 

 

 

 

 

 

 

 

 

 

Charles Runels, MD

 

 

 

 

Cellular Medicine Association
1-888-920-5311

JCPM2022.07.19 Female Genital Mutilation. Melasma. PRP. O-Shot. Carpal Tunnel Syndrome

Topics Discussed Include the Following…

Treating All of the Following with PRP:

  • Melasma

  • Female Genital Mutilation

  • Neuropathy from Carpal Tunnel Syndrome

  • Wound Healing

Questions from Our Members

  1. Morning, Dr. R, may I have price advice for vampire facelift®, and prp Vampire hair®?

  2. I need the information to put on the website to promote my business about Vampire Procedures®

  3. Hi Dr. Runels. I just had a gal from a company called ….. that wanted to meet with me about their product …     She says it will enhance and prolong the success rate of the O shot, especially in women over 45 years old. Have you heard of them? Wanted to touch base with you before I allow an appointment for her to meet with me.

Video/Recording of CMA Journal Club, Pearl Exchange, & Marketing Tips

Relevant Research & Relevant Links

FDA Updates & Warnings with References (click)<—

Next Hands-On Workshops with Live Models<---

Relevant Research

Female Genital Mutilation

Dardeer, H.H.M., M.L. Mohamed, A.M. Elshahat, G.F. Mohammed, and A.M. Gadallah. “Platelet-Rich Plasma: An Effective Modality to Improve Sexuality in FGM/C.” Sexologies, June 2022, S1158136022000457. https://doi.org/10.1016/j.sexol.2022.05.002.

More Research Regarding the O-Shot® Procedure

The first study showing benefit for sex and for urinary function in women with the injection of PRP:  Runels – 2014 – A Pilot Study of the Effect of Localized Injection

More research regarding the O-Shot® procedure<–

Melasma treatment with PRP

Acar, Ayda, Ayris Ozturk, Nur Sokmen, Idil Unal, and Ilgen Ertam Sagduyu. “Evaluation of Platelet-Rich Plasma Efficacy in Melasma,” n.d., 5.

Ojeda, Alejandro González, Gabino Cervantes Guevara, Jonathan Matías Chejfec Ciociano, Guillermo Alonso Cervantes Cardona, Daniel Acevedo Guzman, Ana Graciela Puebla‐Mora, Jose Antonio Cortes Lares, et al. “Treatment of Melasma with Platelet‐rich Plasma: A Self‐controlled Clinical Trial.” Dermatologic Therapy, July 13, 2022. https://doi.org/10.1111/dth.15703.

Wound Healing with PRP (in association with scaffolding materials)

Li, Shangzhi, Qi Dong, Xiaotong Peng, Yun Chen, Hongjun Yang, Weilin Xu, Yanteng Zhao, Pu Xiao, and Yingshan Zhou. “Self-Healing Hyaluronic Acid Nanocomposite Hydrogels with Platelet-Rich Plasma Impregnated for Skin Regeneration,” n.d., 14.

Neuropathy post Carpal Tunnel in diabetes–treatment with Prp

Yasak, Tuğçe, Özay Özkaya, Ayça Ergan Şahin, and Özlem Çolak. “Electromyographic and Clinical Investigation of the Effect of Platelet-Rich Plasma on Peripheral Nerve Regeneration in Patients with Diabetes after Surgery for Carpal Tunnel Syndrome.” Archives of Plastic Surgery 49, no. 02 (March 2022): 200–206. https://doi.org/10.1055/s-0042-1744410.

 

Relevant Links

–>Next class to learn to inject the major joints (knees, elbows, shoulders, Achilles) with PRP<–
–>Apply for Further Online Training for O-Shot®, P-Shot®, Vampire Facelift®, Vampire Breast Lift®, Vampire Wing Lift®, or Vampire Facial®<–
–>Next Hands-on Workshops with Live Models, worldwide <–

–> IMPORTANT (ONLY) IF YOU ARE NEW TO THE CMA: Please take any relevant online tests so that we can immediately list you (and your clinic) on the directories and start supplying you with other helpful marketing and educational materials. Testing takes an hour at most (including watching the videos. If you want to expedite the testing, you can simply call the CMA headquarters (1-888-920-5311 9-5 New York time Mon-Thur; 9-12 Fri) and one of our business consultants will log you in and walk you through where to find the study materials and the tests. If you are already on the directories for the procedure(s) you provide, then you already took the tests or did hand-on training with evaluation by your instructor.

O-Shot® CBD Arousal Oil. O-Shot® providers order wholesale by logging into the O-Shot® membership site, or by calling CMA Headquarters.
Altar™–A Vampire Skin Therapy™. All CMA members can order wholesale by logging into the membership sites and going to Dashboard–>Supplies

 

 

 

 

 

 

 

 

 

 

Charles Runels, MD

 

 

 

 

 

Cellular Medicine Association
1-888-920-5311

JCPM2022.07.19

JCPM2022.07.19

Texted questions:

  1. Morning, Dr. R, may I have price advice for vampire facelift, prp hair?O-Shot 1,200 then 1,000

    P-Shot 1,800 then 1,000

    Vampire Facial $600 per treatment

    Vampire Facelift $1,500 (includes 1 syringe of HA)

    Vampire Hair $600 per treatment

    Vampire Breast Lift $1,800 per treatment (with up to 2 syringes of Juvederm if needed)

  2. I need information to put in website to promote my business about vampire.
  3. Hi Dr Runels. I just had a gal from a company called Xobiologix that wanted to meet with me about their product MaviX. She says it will enhance and prolong the success rate of the O shot especially in women over 45 years old. Have you heard of them? Wanted to touch base with you before I allow an appointment for her to meet with me.

Female Genital Mutilation

Dardeer, H.H.M., M.L. Mohamed, A.M. Elshahat, G.F. Mohammed, and A.M. Gadallah. “Platelet-Rich Plasma: An Effective Modality to Improve Sexuality in FGM/C.” Sexologies, June 2022, S1158136022000457. https://doi.org/10.1016/j.sexol.2022.05.002.

Melasma

Acar, Ayda, Ayris Ozturk, Nur Sokmen, Idil Unal, and Ilgen Ertam Sagduyu. “Evaluation of Platelet-Rich Plasma Efficacy in Melasma,” n.d., 5.

Ojeda, Alejandro González, Gabino Cervantes Guevara, Jonathan Matías Chejfec Ciociano, Guillermo Alonso Cervantes Cardona, Daniel Acevedo Guzman, Ana Graciela Puebla‐Mora, Jose Antonio Cortes Lares, et al. “Treatment of Melasma with Platelet‐rich Plasma: A Self‐controlled Clinical Trial.” Dermatologic Therapy, July 13, 2022. https://doi.org/10.1111/dth.15703.

Wound Healing

Li, Shangzhi, Qi Dong, Xiaotong Peng, Yun Chen, Hongjun Yang, Weilin Xu, Yanteng Zhao, Pu Xiao, and Yingshan Zhou. “Self-Healing Hyaluronic Acid Nanocomposite Hydrogels with Platelet-Rich Plasma Impregnated for Skin Regeneration,” n.d., 14.

Neuropathy post Carpal Tunnel in diabetes

Yasak, Tuğçe, Özay Özkaya, Ayça Ergan Şahin, and Özlem Çolak. “Electromyographic and Clinical Investigation of the Effect of Platelet-Rich Plasma on Peripheral Nerve Regeneration in Patients with Diabetes after Surgery for Carpal Tunnel Syndrome.” Archives of Plastic Surgery 49, no. 02 (March 2022): 200–206. https://doi.org/10.1055/s-0042-1744410.

JCPM2022.07.12

 

BotoxClass.com

References

Botox for Bruxism

Ågren, Martin, Christofer Sahin, and Mattias Pettersson. “The Effect of Botulinum Toxin Injections on Bruxism: A Systematic Review.” Journal of Oral Rehabilitation 47, no. 3 (2020): 395–402. https://doi.org/10.1111/joor.12914.

Fernández-Núñez, T., S. Amghar-Maach, and C. Gay-Escoda. “Efficacy of Botulinum Toxin in the Treatment of Bruxism: Systematic Review.” Medicina Oral, Patologia Oral Y Cirugia Bucal 24, no. 4 (July 1, 2019): e416–24. https://doi.org/10.4317/medoral.22923.

Botox for Depression

Khademi, Mohammad, Masoumeh Roohaninasab, Azadeh Goodarzi, Farnoosh Seirafianpour, Milad Dodangeh, and Arash Khademi. “The Healing Effects of Facial BOTOX Injection on Symptoms of Depression alongside Its Effects on Beauty Preservation.” Journal of Cosmetic Dermatology 20, no. 5 (2021): 1411–15. https://doi.org/10.1111/jocd.13990.

Wollmer, M. Axel, Michelle Magid, Tillmann H. C. Kruger, and Eric Finzi. “The Use of Botulinum Toxin for Treatment of Depression.” In Botulinum Toxin Therapy, edited by Scott M. Whitcup and Mark Hallett, 263:265–78. Handbook of Experimental Pharmacology. Cham: Springer International Publishing, 2019. https://doi.org/10.1007/164_2019_272.

Zamanian, Abbas, Atefeh GHANBARI Jolfaei, and Golnaz Mehran. “Efficacy of Botox versus Placebo for Treatment of Patients with Major Depression,” n.d., 3.

Zhang, Qilin, Wenqi Wu, Yuxin Fan, Yang Li, Jing Liu, Yingying Xu, Caixia Jiang, et al. “The Safety and Efficacy of Botulinum Toxin A on the Treatment of Depression.” Brain and Behavior 11, no. 9 (2021): e2333. https://doi.org/10.1002/brb3.2333.

Botox for Migraine

Chan, Tommy Lik Hang. “OnabotulinumtoxinA Improves Quality of Life in Chronic Migraine: The PREDICT Study.” Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques 49, no. 4 (July 2022): 477–78. https://doi.org/10.1017/cjn.2021.159.

Zandieh, Ali, and Fred Michael Cutrer. “OnabotulinumtoxinA in Chronic Migraine: Is the Response Dose Dependent?” BMC Neurology 22, no. 1 (December 2022): 218. https://doi.org/10.1186/s12883-022-02742-x.

Botox for Stress Headache

Argyriou, Andreas A., Dimos-Dimitrios Mitsikostas, Elisa Mantovani, Michail Vikelis, and Stefano Tamburin. “Beyond Chronic Migraine: A Systematic Review and Expert Opinion on the off-Label Use of Botulinum Neurotoxin Type-A in Other Primary Headache Disorders.” Expert Review of Neurotherapeutics 21, no. 8 (August 3, 2021): 923–44. https://doi.org/10.1080/14737175.2021.1958677.

 

Freund, Brin, and Aruna Rao. “Efficacy of Botulinum Toxin in Tension-Type Headaches: A Systematic Review of the Literature.” Pain Practice 19, no. 5 (2019): 541–51. https://doi.org/10.1111/papr.12773.

 

Gfrerer, Lisa, Wenjie Xu, William Austen, Sait Ashina, Agustin Melo-Carrillo, Maria Serena Longhi, Aubrey Manack Adams, Timothy Houle, Mitchell F Brin, and Rami Burstein. “OnabotulinumtoxinA Alters Inflammatory Gene Expression and Immune Cells in Chronic Headache Patients.” Brain, December 21, 2021, awab461. https://doi.org/10.1093/brain/awab461.

 

Roland, Sissel Breivold, Are Hugo Pripp, Mbachi Ruth Msomphora, and Gunnvald Kvarstein. “The Efficacy of Botulinum Toxin A Treatment for Tension-Type or Cervicogenic Headache: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials.” Scandinavian Journal of Pain 21, no. 4 (October 26, 2021): 635–52. https://doi.org/10.1515/sjpain-2021-0038.

 

Schulte-Mattler, W. J., and J. C. Martinez-Castrillo. “Botulinum Toxin Therapy of Migraine and Tension-Type Headache: Comparing Different Botulinum Toxin Preparations.” European Journal of Neurology 13, no. s1 (2006): 51–54. https://doi.org/10.1111/j.1468-1331.2006.01445.x.

 

 

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